A better phenotyping of patients with HF would be helpful for prognostic stratification and treatment selection. On the other hand, both the diagnosis and treatment of HF with preserved ejection fraction, as well as management of advanced HF and acute HF, remain challenging. Second, vericiguat, an oral soluble guanylate cyclase stimulator, reduced the composite endpoint of cardiovascular death or HF hospitalization vs. In the DAPA-HF and EMPEROR-Reduced trials, dapagliflozin and empagliflozin reduced the risk of the primary composite endpoint, compared with placebo. More recently, new therapeutic pathways have been developed. Sacubitril/valsartan was superior to enalapril in PARADIGM-HF trial, and its initiation during hospitalization for acute HF or early after discharge can now be considered. Landmark trials have established new treatments for HF with reduced ejection fraction.
#AMPED FIVE CHANGE PERSPECTIVE UPDATE#
We give here an update on the most recent findings. Research about heart failure (HF) has made major progress in the last years.
1 Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
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